Big unsuited cards and large connectors play the same as AKs to ATs, except without the flush potential (obviously). You can win big pots with the nut straight, and small to medium pots with pairs and two pairs, but these are not hands to get into major confrontations with. Limp or call small from middle and late position. Of this group of hands Ako or Kqo are the strongest and with these I will limp from early position and make small raises from late position.

Bottom line is these hands look pretty, but they can be dominated and produce very few nut hands. Good hands on a table of expert players but hugely overvalued by 90% of your weaker opponents. I find hands like AQo in early position, and Ajo and ATo generally, so easy to make big Mistakes with, that I regularly toss them away. Personally I prefer the simplicity of a low pocket pair